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Chemical Structure : RGH-560
CAS No.: 2408799-43-7
Catalog No.: PC-21497Not For Human Use, Lab Use Only.
RGH-560 (RGH560) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 190 nM (Ca2+-influx).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RGH-560 (RGH560) is a potent, selective α7 nAChR positive allosteric modulator (PAM) with EC50 of 190 nM (Ca2+-influx).
RGH-560 effectively reverses the scopolamine-induced cognitive impairment with a MED of 10 mg/kg.
RGH-560 is effective in rodent models of cognition, e.g., in the place recognition test.
RGH-560 shows significant cognitive-enhancement in scopolamine-induced amnesia in mice.
| M.Wt | 393.42 | |
| Formula | C22H20FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7'-fluoro-N-((1-methyl-1H-indol-5-yl)methyl)-4'-oxospiro[azetidine-3,2'-chromane]-1-carboxamide |
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1. István Ledneczki, et al. J Med Chem. 2023 Nov 21. doi: 10.1021/acs.jmedchem.3c01635.
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