RGH-706 (RGH706)

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Chemical Structure : RGH-706

Catalog No.: PC-26038Not For Human Use, Lab Use Only.

RGH-706 is a potent, selective and MCH1 receptor (MCHR1) antagonist with IC50 of 6.2 nM (hMCHR1), with no antagonistic activity for hMCHR2.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RGH-706 is a potent, selective and MCH1 receptor (MCHR1) antagonist with IC50 of 6.2 nM (hMCHR1), with no antagonistic activity for hMCHR2.
RGH-706 shows high MCHR1 potency and excellent receptor occupancy profile, translated into statistically significant body weight loss after 14 days in a DIO mice study.

Physicochemical Properties

M.Wt	462.98
Formula	C26H27ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(5-Chloropyridin-2-yl)methoxy]-1-[3-(propan-2-yl)-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indol-9-yl]pyridin-2(1H)-one

References

1. Beke G, et al. J Med Chem. 2026 Jan 22. doi: 10.1021/acs.jmedchem.5c02708.

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RGH-706 (RGH706)

Biological Activity

Physicochemical Properties

References

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