RH1115 | Autophagy activator | Probechem Biochemicals

Chemical Structure : RH1115

RH1115 (RH 1115)

Catalog No.: PC-21540Not For Human Use, Lab Use Only.

RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning.

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Biological Activity

RH1115 is a small molecule activator and inducer of autophagy targeting Lamin A/C and LAMP1, induces changes to LAMP1 vesicle properties and alters lysosome positioning.
RH1115 significantly increase the puncta/cell count in eGFP-LC3 puncta formation assays with EC50 of 46.2 uM.
RH1115 alters positioning of lysosomes and increases autophagic flux in human iPSC-derived neurons.

Physicochemical Properties

M.Wt	356.55
Formula	C23H36N2O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2-Benzyl-8-(cyclohexylmethyl)-2,8-diazaspiro[4.5]decan-4-yl)methanol

References

1. Ryan S Hippman, et al. ACS Chem Neurosci. 2023 Dec 9. doi: 10.1021/acschemneuro.3c00573.

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RH1115 (RH 1115)

Biological Activity

Physicochemical Properties

References

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