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RI-2

Chemical Structure : RI-2

CAS No.: 1417162-36-7

RI-2 (RAD51 inhibitor 2)

Catalog No.: PC-45083Not For Human Use, Lab Use Only.

RI-2 (RAD51 inhibitor 2) is a reversible RAD51 inhibitor with IC50 of 44 uM in the standard DNA binding assays.

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Biological Activity

RI-2 (RAD51 inhibitor 2) is a reversible RAD51 inhibitor with IC50 of 44 uM in the standard DNA binding assays.
RI-2 specifically inhibits HR repair in human cells, sensitize a broad range of immortalized human cells to mitomycin C.

Physicochemical Properties

M.Wt 433.2846
Formula C21H18Cl2N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 15.5 mg/mL

Chemical Name/SMILES

1H-Pyrrole-2,5-dione, 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-(4-morpholinyl)-

References

1. Budke B, et al. J Med Chem. 2013 Jan 10;56(1):254-63.

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