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RIG012

Chemical Structure : RIG012

CAS No.: 2642218-43-5

RIG012 (RIG-012)

Catalog No.: PC-26672Not For Human Use, Lab Use Only.

RIG012 (RIG-012) is a potent small molecule RIG-I receptor inhibitor/antagonist with IC50 of 0.71 uM in NADH-coupled ATPase assays, inhibits RIG-I signaling and interferon response in living cells.

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Biological Activity

RIG012 (RIG-012) is a potent small molecule RIG-I receptor inhibitor/antagonist with IC50 of 0.71 uM in NADH-coupled ATPase assays, inhibits RIG-I signaling and interferon response in living cells.

Physicochemical Properties

M.Wt 359.43
Formula C23H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(Benzyloxy)-3,3-diethyl-2H-benzo[g]indole-2,5(3H)-dione

References

1. David C Rawling, et al. Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. ACS Chem Biol. 2020 Feb 21;15(2):311-317.

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