RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).
RIPGBM is converted to an apoptosis-inducing derivative (cRIPGBM/RIPGBM-18) selectively in GBM CSCs.
cRIPGBM induces apoptosis in GBM CSCs by interacting with RIPK2.
RIPGBM significantly suppress tumor formation in vivo in orthotopic intracranial GBM CSC tumor xenograft mouse model.
