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RIPK1 inhibitor 3-47

Chemical Structure : RIPK1 inhibitor 3-47

CAS No.: 2866461-61-0

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RIPK1 inhibitor 3-47

Catalog No.: PC-25543Not For Human Use, Lab Use Only.

RIPK1 inhibitor 3-47 is a specific, allosteric small molecule inhibitor of RIPK1, effectively reduces phosphorylation of RIPK1 at 12 nM in WB assays (human NP cells), protects viability of TNF-α-treated NP cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RIPK1 inhibitor 3-47 is a specific, allosteric small molecule inhibitor of RIPK1, effectively reduces phosphorylation of RIPK1 at 12 nM in WB assays (human NP cells), protects viability of TNF-α-treated NP cells.
3-47 effectively reduces TNF-α-induced PANoptosis and degeneration of NP cells.
3-47 alleviates PANoptosis phenotype and degenerative phenotype in mice LSI model by inhibiting RIPK1 phosphorylation.

Physicochemical Properties

M.Wt 417.49
Formula C22H19N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-benzyl-N-(7-ethynyl-5-methyl-4-thioxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-1H-1,2,4-triazole-3-carboxamide

References

1. Zhu Z, et al. Apoptosis. 2025 Sep 16. doi: 10.1007/s10495-025-02169-y.

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