RIPK2 inhibitor 8 is a potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
RIPK2 inhibitor 8 displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel.
RIPK2 inhibitor 8 effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM.
RIPK2 inhibitor 8 significantly reverses MDP-induced pro-inflammatory cytokines in rat colon
