RIPK2 inhibitor 8 |CAS 2141969-56-2 Probechem Biochemicals

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Chemical Structure : RIPK2 inhibitor 8

CAS No.: 2141969-56-2

RIPK2 inhibitor 8 (RIPK2-IN-8)

Catalog No.: PC-60160Not For Human Use, Lab Use Only.

RIPK2 inhibitor 8 is a potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RIPK2 inhibitor 8 is a potent, selective, orally available RIPK2 inhibitor with IC50 of 3 nM.
RIPK2 inhibitor 8 displays 90% percent of kinases showed <50% inhibition in a broad 250 kinase panel.
RIPK2 inhibitor 8 effectively suppresses IL6 secrection in mouse bone marrow derived macrophages with IC50 of 12 nM.
RIPK2 inhibitor 8 significantly reverses MDP-induced pro-inflammatory cytokines in rat colon

Physicochemical Properties

M.Wt	392.449
Formula	C18H21FN4O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6-(tert-butylsulfonyl)-7-ethoxyimidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine

References

1. He X, et al. ACS Med Chem Lett. 2017 Sep 27;8(10):1048-1053.

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RIPK2 inhibitor 8 (RIPK2-IN-8)

Biological Activity

Physicochemical Properties

References

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