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Chemical Structure : RJR-2403 hemioxalate
CAS No.:
Catalog No.: PC-43406Not For Human Use, Lab Use Only.
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $568 | In stock |
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RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors; RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes with EC50 of 732 nM; significantly improves passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats, also demonstrates greatly reduced cardiovascular effects; exerts its antinociceptive effect via nicotinic rather than either opioid or muscarinic mechanisms.
| M.Wt | 207.23 | |
| Formula | C11H15N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine hemioxalate |
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1. Bencherif M, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
2. Lippiello PM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
3. Damaj MI, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.
4. Ueno K, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):95-100.
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