Chemical Structure : RJR-2403 oxalate
CAS No.:
220662-95-3
RJR-2403 oxalate
((E)-Metanicotine oxalate;Rivanicline oxalate;RJR 2403 oxalate)
Catalog No.: PC-43404Not For Human Use, Lab Use Only.
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors; RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes with EC50 of 732 nM; significantly improves passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats, also demonstrates greatly reduced cardiovascular effects; exerts its antinociceptive effect via nicotinic rather than either opioid or muscarinic mechanisms.
Physicochemical Properties
|
M.Wt
|
252.2664
|
|
Formula
|
C12H16N2O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20 °C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80 °C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in H2O
|
|
Chemical Name/SMILES
|
3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-, ethanedioate (1:1) (9CI)
|
References
1. Bencherif M, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
2. Lippiello PM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
3. Damaj MI, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.
4. Ueno K, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):95-100.
Contact Us
sales@probechem.com
