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Chemical Structure : RJR-2403 oxalate
Catalog No.: PC-43404Not For Human Use, Lab Use Only.
RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors.
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RJR-2403 (Rivanicline, Metanicotine) is a potent, selective neuronal nicotinic ACh (nAChR) agonist with high affinity to rat brain cortex (Ki=26 nM), does not significantly activate muscle type nAChRs or muscarinic receptors; RJR-2403 is comparable to nicotine in activating rat thalamic synaptosomes with EC50 of 732 nM; significantly improves passive avoidance retention after scopolamine-induced amnesia and enhanced both working and reference memory in rats, also demonstrates greatly reduced cardiovascular effects; exerts its antinociceptive effect via nicotinic rather than either opioid or muscarinic mechanisms.
| M.Wt | 252.2664 | |
| Formula | C12H16N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in H2O |
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1. Bencherif M, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1413-21.
2. Lippiello PM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1422-9.
3. Damaj MI, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):390-8.
4. Ueno K, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):95-100.
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