Catalog No.: PC-35703Not For Human Use, Lab Use Only.
RK-287107 (RK287107) is a novel potent, tankyrase-specific inhibitor with IC50 of 14.3 and 10.6 nM for tankyrase-1 (TNKS1) and tankyrase-2 (TNKS2) respectively, shows no activity against PARP-1.
RK-287107 (RK287107) is a novel potent, tankyrase-specific inhibitor with IC50 of 14.3 and 10.6 nM for tankyrase-1 (TNKS1) and tankyrase-2 (TNKS2) respectively, shows no activity against PARP-1.
RK-287107 shows 4-8-fold more potency than G007-LK; causes Axin2 accumulation and downregulates β-catenin, T-cell factor/lymphoid enhancer factor reporter activity and the target gene expression in colorectal cancer cells harboring the shortly truncated APC mutations.
RK-287107 inhibits the growth of APC-mutated (β-catenin-dependent) colorectal cancer COLO-320DM and SW403 cells but not the APC-wild (β-catenin-independent) colorectal cancer RKO cells.
RK-287107 suppresses COLO-320DM tumor growth in NOD-SCID mice (intraperitoneal or oral administration).
