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RM1490

Chemical Structure : RM1490

CAS No.: 2849392-47-6

RM1490 (RM 1490)

Catalog No.: PC-49745Not For Human Use, Lab Use Only.

RM1490 (RM 1490) is a potent, brain-penetrant µ opioid receptor (MOR) agonist with EC50 of 3.4 and 4.4 nM in GTPγS and cAMP assays, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RM1490 (RM 1490) is a potent, brain-penetrant µ opioid receptor (MOR) agonist with EC50 of 3.4 and 4.4 nM in GTPγS and cAMP assays, respectively.
RM1490 inhibits the cAMP response to DAMGO in competition assays.
RM1490 exhibits approximately half the intrinsic MOR efficacy of buprenorphine.
RM1490 (3 mg/kg) dose-dependently reduces the number of writhes in acetic acid–induced writhing.
RM1490 has a physiological and behavioral profile suitable for opioid use disorder maintenance therapy.

Physicochemical Properties

M.Wt 394.56
Formula C25H34N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-3-cyclopropyl-N-((S)-2-(dimethylamino)-3-(4-hydroxy-2,6-dimethylphenyl)propyl)-3-phenylpropanamide

References

1. Beth Youngblood, et al. J Pharmacol Exp Ther. 2021 Aug;378(2):133-145.

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