RNF4 PROTAC RD12 | RNF4 degrader | Probechem Biochemicals

You are here:Home-ADCs and PROTACs-PROTAC-RNF4 PROTAC RD12

Chemical Structure : RNF4 PROTAC RD12

RNF4 PROTAC RD12 (RNF4 degrader)

Catalog No.: PC-26975Not For Human Use, Lab Use Only.

RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage.

Packing	Price	Stock	Quantity
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RNF4 PROTAC RD12 is a first-in-class, selective Ring Finger Protein 4 (RNF4) PROTAC degrader, selectively degrades RNF4 through UPS and induces DNA damage.
RD12 is capable of inducing RNF4 protein degradation in multiple HCC cell lines (HepG2, HCCLM6, Huh7).
RD12 displays profound antiproliferative activity both in vitro and in vivo.
RD12 elicits a significant anti-tumor effect in a HCC mouse model.

Physicochemical Properties

M.Wt	866.47
Formula	C47H52ClN5O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

References

1. Hui Wan, et al. Eur J Med Chem. 2026 Apr 5:307:118668.

Overnight Delivery
Fast & Safe Delivery Worldwide
Rewards Program

About Us

Our Services

Site Map

Join with Us
Product Use Citations

Pharmacological Glossary Abbreviations

Abbreviations

Quality Manual

Inquiry Form
How to Order

Terms & Conditions

Credit Card Payment

Shipping Rates & Policies

Privacy Policy
sales@probechem.com