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Chemical Structure : RNPA1000
Catalog No.: PC-43233Not For Human Use, Lab Use Only.
RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.
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RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth; does not affect the activity of the E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at 750 uM; also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus (S. aureus MRSA USA100 strain MIC=26 ug/mL) and protects against the S. aureus pathogenesis in an animal model of infection.
| M.Wt | 464.3113 | |
| Formula | C23H18BrN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Olson PD, et al. PLoS Pathog. 2011 Feb 10;7(2):e1001287.
2. Eidem TM, et al.
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