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Chemical Structure : RNPA1000
CAS No.: 359600-10-5
Catalog No.: PC-43233Not For Human Use, Lab Use Only.
RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.
RNPA1000 does not affect the activity of the E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at 750 uM.
RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus (S. aureus MRSA USA100 strain MIC=26 ug/mL) and protects against the S. aureus pathogenesis in an animal model of infection.
| M.Wt | 464.3113 | |
| Formula | C23H18BrN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]- |
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1. Olson PD, et al. PLoS Pathog. 2011 Feb 10;7(2):e1001287.
2. Eidem TM, et al. J Biomater Appl. 2014 Apr;28(8):1235-46.
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