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RNPA2000

Chemical Structure : RNPA2000

CAS No.: 329214-04-2

RNPA2000 (RNPA 2000)

Catalog No.: PC-63264Not For Human Use, Lab Use Only.

RNPA2000 is a small-molecule inhibitor of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing (IC50=130 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RNPA2000 is a small-molecule inhibitor of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing (IC50=130 uM); inhibits both RnpA-associated RNA degradation and tRNA maturation activities both in vitro and within S. aureus.

Physicochemical Properties

M.Wt 361.416
Formula C17H19N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2-(4-isopropylphenoxy)acetyl)hydrazine-1-carbonothioyl)furan-2-carboxamide

References

1. Eidem TM, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):2016-28.

2. Lounsbury N, et al. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1127-1131.

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