Chemical Structure : RO-02
CAS No.:
1185017-00-8
RO-02
(RO5434400)
Catalog No.: PC-24101Not For Human Use, Lab Use Only.
RO-02 (RO5434400) is a small molecule γ-secretase modulator (GSM), lowers Aβ42 species in HEK293 cells stably expressing the APPsw mutant (HEK293/sw) with IC50 of 12 nM, lowers Aβ40 and Aβ42 generation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RO-02 (RO5434400) is a small molecule γ-secretase modulator (GSM), lowers Aβ42 species in HEK293 cells stably expressing the APPsw mutant (HEK293/sw) with IC50 of 12 nM, lowers Aβ40 and Aβ42 generation.
RO-02 increases the short species Aβ38, and also inhibits Aβ40 formation.
RO-02 exhibits potent and preferential Aβ42-lowering activity of RO-02 was confirmed in rat primary cortical neurons (IC50 (Aβ42) =13 nM).
RO-02 modulates the generation of Aβ species by γ-secretase from the recombinant APP substrate C100-His6 as expected (IC50 (Aβ42) = 0.5 uM) and without affecting the levels of total Aβ and total AICD in cell-free in vitro assays.
Physicochemical Properties
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M.Wt
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463.97
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Formula
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C25H26ClN5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(6-(4-chlorobenzyl)-2-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)amino)pyrimidin-4-yl)propan-2-ol
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References
1. Ebke A, et al. J Biol Chem. 2011;286:37181–6.
2. Trambauer J, et al. EMBO Rep. 2020 Jan 7;21(1):e47996.
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