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Chemical Structure : RO-275
Catalog No.: PC-21477Not For Human Use, Lab Use Only.
RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.
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RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.
RO-275 also shows no activity against other ion channels, including hERG and Nav1.5.
RO-275 (3, 10, or 30 mg/kg i.p.) improves performance in a rodent working memory paradigm.
RO-275 (30 mg/kg) partially rescued performance impairment by MK-801.
RO-275 does not affect electrophysiological properties of hiPSC-derived atrial-like cardiomyocytes nor heart rate in rats.
| M.Wt | 351.79 | |
| Formula | C18H14ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Harde E, et al. Cell Chem Biol. 2023 Nov 24:S2451-9456(23)00419-1.
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