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RO-275

Chemical Structure : RO-275

CAS No.: 2648837-04-9

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RO-275 (RO275, RO 275)

Catalog No.: PC-21477Not For Human Use, Lab Use Only.

RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4.
RO-275 also shows no activity against other ion channels, including hERG and Nav1.5.
RO-275 (3, 10, or 30 mg/kg i.p.) improves performance in a rodent working memory paradigm.
RO-275 (30 mg/kg) partially rescued performance impairment by MK-801.
RO-275 does not affect electrophysiological properties of hiPSC-derived atrial-like cardiomyocytes nor heart rate in rats.

Physicochemical Properties

M.Wt 351.79
Formula C18H14ClN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((2-chloro-3-methylpyridin-4-yl)ethynyl)-5-methyl-1-(pyridin-3-yl)-1H-imidazole-2-carboxamide

References

1. Harde E, et al. Cell Chem Biol. 2023 Nov 24:S2451-9456(23)00419-1.

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