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Chemical Structure : RO-7
Catalog No.: PC-62616Not For Human Use, Lab Use Only.
RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells.
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RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells; inhibits transcription and genome replication steps in the influenza virus cycle, demonstrates activity against NAI-resistant and -susceptible seasonal influenza A and B viruses; also shows activity against avian-origin A(H5N1), A(H7N9), and A(H9N2) influenza viruses.
| M.Wt | 487.497 | |
| Formula | C24H20F3N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jones JC, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02460-16.
2. Jones JC, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5504-14.
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