Chemical Structure : RO-7
CAS No.:
1370241-45-4
RO-7
(RO7)
Catalog No.: PC-62616Not For Human Use, Lab Use Only.
RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RO-7 is a novel small molecule, broad-spectrum inhibitor of influenza acidic polymerase (PA) protein endonuclease activity with EC50 of 3.2-16 nM in MDCK cells; inhibits transcription and genome replication steps in the influenza virus cycle, demonstrates activity against NAI-resistant and -susceptible seasonal influenza A and B viruses; also shows activity against avian-origin A(H5N1), A(H7N9), and A(H9N2) influenza viruses.
Physicochemical Properties
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M.Wt
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487.497
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Formula
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C24H20F3N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-((S)-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-5-hydroxy-3-((R)-1,1,1-trifluoropropan-2-yl)-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione
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References
1. Jones JC, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02460-16.
2. Jones JC, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5504-14.
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