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RO-9187

Chemical Structure : RO-9187

CAS No.: 876708-03-1

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RO-9187 (RO 9187, RO9187)

Catalog No.: PC-42722Not For Human Use, Lab Use Only.

RO-9187 is a potent HCV NS5B RNA polymerase inhibitor, inhibits HCV replication in the replicon system with IC50 of 171 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RO-9187 is a potent HCV NS5B RNA polymerase inhibitor,  inhibits HCV replication in the replicon system with IC50 of 171 nM.
RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations (IC50=600-1100 nM).
RO-9187 shows good oral bioavailability in rats and no toxicologically significant findings.

Physicochemical Properties

M.Wt 284.2288
Formula C9H12N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Pyrimidinone, 4-amino-1-(4-C-azido-β-D-arabinofuranosyl)-

References

1. Klumpp K, et al. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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