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RO 5126946

Chemical Structure : RO 5126946

CAS No.: 1137233-79-4

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RO 5126946 (RO5126946, RO-5126946)

Catalog No.: PC-60794Not For Human Use, Lab Use Only.

RO 5126946 is a potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RO 5126946 is a potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.
    RO 5126946 shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors.
    RO 5126946 enhances α7nAChR synaptic transmission and positively modulates GABAergic responses.
    RO 5126946 improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.

    Physicochemical Properties

    M.Wt 408.897
    Formula C19H21ClN2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamide

    References

    1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68.

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