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Chemical Structure : RO 5126946
Catalog No.: PC-60794Not For Human Use, Lab Use Only.
A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.
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A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.
| M.Wt | 408.897 | |
| Formula | C19H21ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68.
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