RO 5126946 |CAS:1137233-79-4 Probechem Biochemicals

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Chemical Structure : RO 5126946

RO 5126946 (RO5126946;RO-5126946)

Catalog No.: PC-60794Not For Human Use, Lab Use Only.

A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent, selective, orally bioavailable and brain-penetran α7nAChR positive allosteric modulator with EC50 of 60 nM; shows excellent selectivity over α4β2nAChR and 5-hydroxytryptamine 3 receptors; enhances α7nAChR synaptic transmission and positively modulates GABAergic responses; improves associative learning in a scopolamine-induced deficit model of fear conditioning in rats, potentiates nicotine's effects on fear memory in vivo.

Physicochemical Properties

M.Wt	408.897
Formula	C19H21ClN2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N-[(1S,3R)-2,2-dimethyl-3-(4-sulfamoyl-phenyl)-cyclopropyl]-2-methoxy-benzamide

References

1. Sahdeo S, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):455-68.

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RO 5126946 (RO5126946;RO-5126946)

Biological Activity

Physicochemical Properties

References

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