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Chemical Structure : RO5508887
Catalog No.: PC-61044Not For Human Use, Lab Use Only.
RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
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RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
RO5508887 (RG7129) has IC50 of 18 nM in HEK293APP cells and in neuronal cultures derived from human neuronal stem cells.
RO5508887 (RG7129) significantly enhances antiamyloid effect combined with gantenerumab.
| M.Wt | 389.338 | |
| Formula | C18H14F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jacobsen H, et al. J Neurosci. 2014 Aug 27;34(35):11621-30.
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