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RO5508887

Chemical Structure : RO5508887

CAS No.: 1310347-50-2

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RO5508887 (RO 5508887, RG-7129, RG7129)

Catalog No.: PC-61044Not For Human Use, Lab Use Only.

RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RO5508887 (RG7129) is a potent, selective BACE inhibitor with IC50 of 30 nM for BACE1, equally potent against BACE2 (IC50=40 nM) but >1,000-fold selectivity over cathepsin D, cathepsin E, pepsin and renin.
    RO5508887 (RG7129) has IC50 of 18 nM in HEK293APP cells and in neuronal cultures derived from human neuronal stem cells.
    RO5508887 (RG7129) significantly enhances antiamyloid effect combined with gantenerumab.

    Physicochemical Properties

    M.Wt 389.338
    Formula C18H14F3N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-Cyano-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluorophenyl]amide

    References

    1. Jacobsen H, et al. J Neurosci. 2014 Aug 27;34(35):11621-30.

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