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Chemical Structure : RO7075573
Catalog No.: PC-21952Not For Human Use, Lab Use Only.
RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606.
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RO7075573 is a small-molecule, tethered macrocyclic peptide antibiotic targeting the lipopolysaccharide transporter, has MIC of 0.12 ug/mL A. baumannii ATCC 19606.
RO7075573 exhibits vivo efficacy with 0.12 mg/L in mouse model of infection induced by A. baumannii ACC00535.
RO7075573 is 4- to 64-fold more potent than RO7036668 against a panel of A. baumannii, and displays selectivity against Acinetobacter (MIC > 64 mg/L).
RO7075573 is inactive against wild-type and efflux-impaired and porin-deficient Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
| M.Wt | 739.76 | |
| Formula | C36H44Cl2N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Claudia Zampaloni, et al. Nature. 2024 Jan;625(7995):566-571.
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