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Chemical Structure : ROC-325
CAS No.: 1859141-26-6
Catalog No.: PC-60599Not For Human Use, Lab Use Only.
ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
ROC-325 exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux.
ROC-325 antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity.
ROC-325 significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
| M.Wt | 503.061 | |
| Formula | C28H27ClN4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one |
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1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.
2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.
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