ROCK inhibitor 23

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Chemical Structure : ROCK inhibitor 23

Catalog No.: PC-49062Not For Human Use, Lab Use Only.

ROCK inhibitor 23 is a potent, selective, and brain-penetrant Rho kinase (ROCK) inhibitor with IC50 of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ROCK inhibitor 23 is a potent, selective, and brain-penetrant Rho kinase (ROCK) inhibitor with IC50 of 6 nM.
ROCK inhibitor 23 could be dosed orally in mice with selectivity against other AGC kinases, including protein kinase G (PKG).
ROCK inhibitor 23 demonstrated a robust pharmacodynamic (PD) effect by the inhibition of ROCK-mediated substrate (MYPT1) phosphorylation (IC50=4 nM).

Physicochemical Properties

M.Wt	372.444
Formula	C20H25FN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(3-fluoropyridin-4-yl)-N-((R)-1-(3-methoxyphenyl)ethyl)-2-methylpiperazine-1-carboxamide

References

1. Tammy Ladduwahetty, et al. J Med Chem. 2022 Jul 11. doi: 10.1021/acs.jmedchem.2c00474.

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