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Chemical Structure : ROMK-IN-25
Catalog No.: PC-62794Not For Human Use, Lab Use Only.
ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM.
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ROMK-IN-25 is a potent and selective renal outer medullary potassium channel (ROMK, Kir1.1, KCNJ1) inhibitor with IC50 of 72 nM.
ROMK-IN-25 displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles.
ROMK-IN-25 does not evoke QTc prolongation in an in vivo cardiovascular dog model.
| M.Wt | 462.489 | |
| Formula | C23H23FN8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zhu Y, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702.
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