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Chemical Structure : ROMK-IN-32
Catalog No.: PC-62832Not For Human Use, Lab Use Only.
ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.
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ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.
ROMK-IN-32 shows an improved functional hERG/ROMK potency ratio (1176x) and preclinical PK profile.
ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model.
| M.Wt | 452.511 | |
| Formula | C24H28N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dong S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566.
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