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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Potassium Channel-ROMK-IN-32
ROMK-IN-32

Chemical Structure : ROMK-IN-32

CAS No.: 1914944-54-9

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ROMK-IN-32

Catalog No.: PC-62832Not For Human Use, Lab Use Only.

ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ROMK-IN-32 is a potent, selective renal outer medullary potassium channel (ROMK, Kir1.1) inhibitor with IC50 of 17 nM.
    ROMK-IN-32 shows an improved functional hERG/ROMK potency ratio (1176x) and preclinical PK profile.
    ROMK-IN-32 demonstrates blood pressure lowering effects in the spontaneously hypertensive rat model.

    Physicochemical Properties

    M.Wt 452.511
    Formula C24H28N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-8-(2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)-2-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)-2,8-diazaspiro[4.5]decan-1-one

    References

    1. Dong S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2559-2566.

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