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RP-67580

Chemical Structure : RP-67580

CAS No.: 135911-02-3

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RP-67580 (RP67580)

Catalog No.: PC-70190Not For Human Use, Lab Use Only.

RP-67580 is a potent and selective tachykinin NK1 receptor antagonist with Ki of 2.9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RP-67580 is a potent and selective tachykinin NK1 receptor antagonist with Ki of 2.9 nM.
    RP-67580 shows no activity ofr NK2 and NK3 (Ki>10 uM).
    RP-67580 exhibits antinociceptive activity in writhing and formalin paw tests in mice and gerbils.

    Physicochemical Properties

    M.Wt 438.57
    Formula C29H30N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3aR,7aR)-Octahydro-2-[1-imino-2-(2-methoxyphenyl)ethyl]-7,7-diphenyl-4H-isoindol-4-one

    References

    1. Rupniak NM, et al. Br J Pharmacol. 1993 Dec;110(4):1607-13.

    2. Beaujouan JC, et al. Br J Pharmacol. 1993 Mar;108(3):793-800.

    3. Fong TM, et al. J Biol Chem. 1992 Dec 25;267(36):25668-71.

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