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Chemical Structure : RP-67580
Catalog No.: PC-70190Not For Human Use, Lab Use Only.
RP-67580 is a potent and selective tachykinin NK1 receptor antagonist with Ki of 2.9 nM.
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RP-67580 is a potent and selective tachykinin NK1 receptor antagonist with Ki of 2.9 nM.
RP-67580 shows no activity ofr NK2 and NK3 (Ki>10 uM).
RP-67580 exhibits antinociceptive activity in writhing and formalin paw tests in mice and gerbils.
| M.Wt | 438.57 | |
| Formula | C29H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rupniak NM, et al. Br J Pharmacol. 1993 Dec;110(4):1607-13.
2. Beaujouan JC, et al. Br J Pharmacol. 1993 Mar;108(3):793-800.
3. Fong TM, et al. J Biol Chem. 1992 Dec 25;267(36):25668-71.
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