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Chemical Structure : RP12146
Catalog No.: PC-72312Not For Human Use, Lab Use Only.
RP12146 (RP12146) is a novel, selective, and potent small molecule inhibitor of PARP1/2 with IC50 of 0.6/0.5 nM, with several fold selectivity over other isoforms.
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RP12146 (RP12146) is a novel, selective, and potent small molecule inhibitor of PARP1/2 with IC50 of 0.6/0.5 nM, with several fold selectivity over other isoforms.
RP12146 inhibited cell growth in both BRCA mutant and non-BRCA mutant cancer cell lines with a GI50 range of 0.043 to 19.83 µM in a dose dependent manner.
RP12146 demonstrated anti-tumor activities in both tumor size and tumor weight in OVCAR3 xenograft model.
| M.Wt | 398.422 | |
| Formula | C23H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO2021220120 A1.
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