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Chemical Structure : RPR260243
Catalog No.: PC-60839Not For Human Use, Lab Use Only.
RPR260243 is a potent, selective hERG potassium channel (Kv11.1) activator that dramatically slows current deactivation at 1-30 uM.
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RPR260243 is a potent, selective hERG potassium channel (Kv11.1) activator that dramatically slows current deactivation at 1-30 uM.
RPR260243-modified HERG currents is inhibited by dofetilide (IC50=58 nM), has little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes, and no activator-like effects on other voltage-dependent ion channels, including the erg3 K+ channel.
RPR260243 completely reverses the action potential-prolonging effects of dofetilide in guinea pig myocytes.
| M.Wt | 510.513 | |
| Formula | C28H25F3N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kang J, et al. Mol Pharmacol. 2005 Mar;67(3):827-36.
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