RSK2-IN-20 |CAS:1627136-55-3 Probechem Biochemicals

Chemical Structure : RSK2-IN-20

RSK2-IN-20

Catalog No.: PC-62854Not For Human Use, Lab Use Only.

RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM.

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Biological Activity

RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM.
RSK2-IN-20 shows high selectivity over NEK2, PLK1.
RSK2-IN-20 potently inhibits MSK1 autophosphorylation in cells, and has no significant effect on a panel of 18 additional kinases.

Physicochemical Properties

M.Wt	402.414
Formula	C21H18N6O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(1H-1,2,4-triazol-1-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylonitrile

References

1. Krishnan S, et al. J Am Chem Soc. 2014 Sep 10;136(36):12624-30.

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RSK2-IN-20

Biological Activity

Physicochemical Properties

References

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