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Chemical Structure : RSV604
CAS No.: 676128-63-5
Catalog No.: PC-43309Not For Human Use, Lab Use Only.
RSV604 (RSV-604) is a potent respiratory syncytial virus (RSV) inhibitor with EC50 of 0.86 uM in XTT assay, targets the nucleocapsid protein and is active post-RSV infection.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | Get quote |
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RSV604 (RSV-604) is a potent respiratory syncytial virus (RSV) inhibitor with EC50 of 0.86 uM in XTT assay, targets the nucleocapsid protein and is active post-RSV infection.
RSV604 is also equipotent against 40 clinical isolates of RSV with an average EC50 of 0.8 μM by plaque reduction assay.
The mutations (N105D, I129L, L139I, and I129L with L139I) within the nucleocapsid protein confer 5->20-fold reduced potentcy for RSV604.
RSV604 inhibits virus replication after mucosal inoculation in human airway epithelial cell model (EC50=0.5-0.9 uM).
| M.Wt | 388.3944 | |
| Formula | C22H17FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 195 mg/mL |
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| Chemical Name/SMILES |
Urea, N-[(3S)-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-N'-(2-fluorophenyl)- |
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1. Henderson EA, et al. J Med Chem. 2007 Apr 5;50(7):1685-92.
2. Chapman J, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53.
3. Challa S, et al. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.
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