RSV RdRp inhibitor Compound 22

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Chemical Structure : RSV RdRp inhibitor Compound 22

Catalog No.: PC-24701Not For Human Use, Lab Use Only.

RSV RdRp inhibitor Compound 22 is a novel non-nucleoside inhibitor of RSV RNA-dependent RNA polymerase (RdRp) with IC50 of 0.27 uM, binds to a novel site in the palm domain of RdRp (SPR KD=0.47 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RSV RdRp inhibitor Compound 22 is a novel non-nucleoside inhibitor of RSV RNA-dependent RNA polymerase (RdRp) with IC50 of 0.27 uM, binds to a novel site in the palm domain of RdRp (SPR KD=0.47 uM).
Compound 22 exhibits cellular activity in RSV eGFP phenotypic assay in HeLa cells with EC50 of 2.38 uM.
Compound 22 is similarly efficacious at inhibiting replication of clinically isolated RSV A and B strains as determined by quantitative reverse transcription PCR (RT-qPCR).

Physicochemical Properties

M.Wt	431.72
Formula	C19H16BrClN4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(5-bromo-1-methyl-2-oxospiro[indoline-3,4'-piperidin]-1'-yl)-3-chloropicolinonitrile

References

1. Kalin JH, et al. J Virol. 2025 Jun 2:e0017825.

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