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Chemical Structure : RSV inhibitor compound 1
Catalog No.: PC-35761Not For Human Use, Lab Use Only.
RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM).
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RSV inhibitor compound 1 is a novel potent, orally bioavailable RSV fusion inhibitor with EC50 of 2 nM (RSV Long strain infected HEp-2 cells) without significant cytotoxicity (CC50>100 uM); demonstrats single-digit nM anti-RSV activity against different RSV strains (RSV A2, RSV B with EC50 of 4 and 2 nM); also displays 1 log viral reduction in a female BALB/c mice RSV model by b.i.d. oral dosing at 12.5 mg/kg.
| M.Wt | 438.546 | |
| Formula | C23H26N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Zheng X, et al. J Med Chem. 2018 Nov 2. doi: 10.1021/acs.jmedchem.8b01394.
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