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Chemical Structure : RTI-13951-33
CAS No.: 2244884-08-8
Catalog No.: PC-35398Not For Human Use, Lab Use Only.
RTI-13951-33 is a potent, selective, brain-penetrant agonist of the orphan receptor GPR88 with EC50 of 25 nM in in vitro cAMP functional assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $228 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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RTI-13951-33 is a potent, selective, brain-penetrant agonist of the orphan receptor GPR88 with EC50 of 25 nM in in vitro cAMP functional assay.
RTI-13951-33 displays no significant off-target activity at 38 GPCRs, ion channels, and neurotransmitter transporters.
RTI-13951-33 exhibits enhanced aqueous solubility compared to (1R,2R)-2-PCCA (2) and had favorable pharmacokinetic properties for behavioral assessment.
RTI-13951-33 significantly reduces alcohol self-administration and alcohol intake in a dose-dependent manner without effects on locomotion and sucrose self-administration in rats
| M.Wt | 459.59 | |
| Formula | C28H33N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(1R,2R)-N-((2R,3R)-2-amino-3-methoxybutyl)-N-(4'-(methoxymethyl)-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide |
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1. Jin C, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00566.
2. Ye N, et al. ACS Chem Neurosci. 2018 Dec 12. doi: 10.1021/acschemneuro.8b00572.
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