Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-RU-301
RU-301

Chemical Structure : RU-301

CAS No.: 1110873-99-8

Add to Favorites

RU-301 (RU 301, RU301)

Catalog No.: PC-60246Not For Human Use, Lab Use Only.

RU-301 (RU301) is a small molecule pan-TAM (Tyro3-Axl-Mer)) inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.

Packing Price Stock Quantity
5 mg $198 In stock
10 mg $298 In stock
25 mg $488 In stock
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RU-301 (RU301) is a small molecule pan-TAM (Tyro3-Axl-Mer)) inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-301 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-301 inhibits Gas6-inducible motility in Axl-expressing cell lines.
RU-301 suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.

Physicochemical Properties

M.Wt 480.462
Formula C21H19F3N4O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((3-methylisoxazol-5-yl)methyl)thio)-N-(2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide

References

1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: