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Chemical Structure : RU-301
CAS No.: 1110873-99-8
Catalog No.: PC-60246Not For Human Use, Lab Use Only.
RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RU-301 (RU301) is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-301 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-301 inhibits Gas6-inducible motility in Axl-expressing cell lines.
RU-301 suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.
| M.Wt | 480.462 | |
| Formula | C21H19F3N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(((3-methylisoxazol-5-yl)methyl)thio)-N-(2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide |
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1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.
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