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Chemical Structure : RU-302
CAS No.: 1182129-77-6
Catalog No.: PC-60247Not For Human Use, Lab Use Only.
RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-302 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-302 inhibits Gas6-inducible motility in Axl-expressing cell lines, and suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.
| M.Wt | 475.53 | |
| Formula | C24H24F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone |
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1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.
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