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RU-302

Chemical Structure : RU-302

CAS No.: 1182129-77-6

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RU-302 (RU 302;RU302)

Catalog No.: PC-60247Not For Human Use, Lab Use Only.

RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.

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5 mg $128 In stock
10 mg $198 In stock
25 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RU-302 is a small molecule pan-TAM inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-302 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-302 inhibits Gas6-inducible motility in Axl-expressing cell lines, and suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.

Physicochemical Properties

M.Wt 475.53
Formula C24H24F3N3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2-(((3,5-dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone

References

1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.

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