RU-A1 | BMI-1 inhibitor | Probechem Biochemicals

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Chemical Structure : RU-A1

RU-A1 (BMI-1 inhibitor RU-A1)

Catalog No.: PC-61790Not For Human Use, Lab Use Only.

RU-A1 is a novel potent BMI1 inhibitor that targets cellular self-renewal in hepatocellular carcinoma (HCC).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RU-A1 is a novel potent BMI1 inhibitor that targets cellular self-renewal in hepatocellular carcinoma (HCC).
RU-A1 downregulates BMI1 expression, impaires cell viability, reduces cell migration, and sensitizes HCC cells to 5-FU in vitro.
RU-A1 effectively reduces cancer stem-like cells (CSCs) content, and abrogates tumor growth in vivo in zebrafish.

Physicochemical Properties

M.Wt	337.401
Formula	C17H15N5OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine

References

1. Bartucci M, et al. Target Oncol. 2017 Aug;12(4):449-462.

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RU-A1 (BMI-1 inhibitor RU-A1)

Biological Activity

Physicochemical Properties

References

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