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Chemical Structure : RV1088
Catalog No.: PC-63408Not For Human Use, Lab Use Only.
RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM.
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RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM.
RV1088 also reduces IL-6 production effectively with IC50 of 1.66 nM.
RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.
| M.Wt | 578.673 | |
| Formula | C33H34N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16.
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