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RX-105

Chemical Structure : RX-105

CAS No.: 449767-89-9

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RX-105 (RX105)

Catalog No.: PC-20581Not For Human Use, Lab Use Only.

RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).
    RX-105 inhibited binding of L-selectin to heparin with IC50 of 15 uM, inhibited selectin, chemokine and cytokine binding to GAGs.
    RX-105 (5-50 mg/kg) inhibited paw edema dose dependently in paw edema animal model.

    Physicochemical Properties

    M.Wt 582.80
    Formula C29H34N4O3S3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(3-(benzo[d]thiazol-2-yl)-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-4-(N-butyl-N-ethylsulfamoyl)benzamide

    References

    1. Nicholas Harris, et al. Biochim Biophys Acta. 2014 Jan;1840(1):245-54.

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