RX-105 | | Probechem Biochemicals

Chemical Structure : RX-105

RX-105 (RX105)

Catalog No.: PC-20581Not For Human Use, Lab Use Only.

RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).

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Biological Activity

RX-105 (RX105) is a small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs) with anti-inflammatory properties, binds directly to glycosaminoglycans (GAGs).
RX-105 inhibited binding of L-selectin to heparin with IC50 of 15 uM, inhibited selectin, chemokine and cytokine binding to GAGs.
RX-105 (5-50 mg/kg) inhibited paw edema dose dependently in paw edema animal model.

Physicochemical Properties

M.Wt	582.80
Formula	C29H34N4O3S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(NC(S1)=C(C2=NC3=CC=CC=C3S2)C4=C1CN(CC)CC4)C5=CC=C(S(=O)(N(CCCC)CC)=O)C=C5

References

1. Nicholas Harris, et al. Biochim Biophys Acta. 2014 Jan;1840(1):245-54.

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RX-105 (RX105)

Biological Activity

Physicochemical Properties

References

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