Catalog No.: PC-38493Not For Human Use, Lab Use Only.
RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).
RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).
RY785 also displays no significant activity against CaV channel, and NaV channels.
RY785 (1 uM) block eliminates Kv2.1 current at all physiologically relevant voltages, inhibiting ≥98% of the Kv2.1 conductance in rat Kv2.1 (Kcnb1) channels heterologously expressed in CHO-K1 cells.
RY785 is an important chemical probe for the study of K(V)2 channels in biological systems.
