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Chemical Structure : RY785
CAS No.: 689297-68-5
Catalog No.: PC-38493Not For Human Use, Lab Use Only.
RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $388 | In stock | |
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RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).
RY785 also displays no significant activity against CaV channel, and NaV channels.
RY785 (1 uM) block eliminates Kv2.1 current at all physiologically relevant voltages, inhibiting ≥98% of the Kv2.1 conductance in rat Kv2.1 (Kcnb1) channels heterologously expressed in CHO-K1 cells.
RY785 is an important chemical probe for the study of K(V)2 channels in biological systems.
| M.Wt | 392.477 | |
| Formula | C21H20N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(3-methoxyphenyl)-2-methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)propanamide |
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1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64.
2. Marquis MJ, et al. J Gen Physiol. 2022 Jun 6;154(6):e202112981.
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