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Chemical Structure : RY796
Catalog No.: PC-60669Not For Human Use, Lab Use Only.
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively.
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RY796 is a potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively.
RY796 shows no significant activity against Kv1.2 and Kv7.1, and Cav channels.
RY796 enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.
| M.Wt | 353.466 | |
| Formula | C21H27N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64.
2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16.
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