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Chemical Structure : RY796 racemate
Catalog No.: PC-60805Not For Human Use, Lab Use Only.
A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively.
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A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.
| M.Wt | 353.466 | |
| Formula | C21H27N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64.
2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16.
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