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Rabeprazole

Chemical Structure : Rabeprazole

CAS No.: 117976-89-3

Rabeprazole (LY307640)

Catalog No.: PC-24038Not For Human Use, Lab Use Only.

Rabeprazole (LY307640) is a second-generation proton pump inhibitor that irreversibly inactivates gastric H+/K+-ATPase, also is an uridine nucleoside ribohydrolase (UNH) inhibitor with IC50 of 0.3 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Rabeprazole (LY307640) is a second-generation proton pump inhibitor that irreversibly inactivates gastric H+/K+-ATPase, also is an uridine nucleoside ribohydrolase (UNH) inhibitor with IC50 of 0.3 uM.
Rabeprazole inhibits the phosphorylation of ERK1/2 in the MKN-28 cells.
Rabeprazole attenuates the cell viability of the human gastric cancer cells.

Physicochemical Properties

M.Wt 359.44
Formula C18H21N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole

References

1. Tara A Shea, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.

2. Mengli Gu, et al. Oncol Lett. 2014 Oct;8(4):1739-1744.

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