Chemical Structure : Radalbuvir
CAS No.:
1314795-11-3
Radalbuvir
(GS 9669)
Catalog No.: PC-63008Not For Human Use, Lab Use Only.
Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.
Radalbuvir (GS-9669) shows inhibition of WT genotype 1b replicon and NS5B M423T mutant replicon with EC50 of 6 nM and 12 nM respectively.
Physicochemical Properties
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M.Wt
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543.719
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Formula
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C30H41NO6S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)-
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References
1. Lazerwith SE, et al. J Med Chem. 2014 Mar 13;57(5):1893-901.
2. Fenaux M, et al. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10.
3. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6599-606.
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