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Radicicol

Chemical Structure : Radicicol

CAS No.: 12772-57-5

Radicicol (Monorden)

Catalog No.: PC-23745Not For Human Use, Lab Use Only.

Radicicol is an inhibitor of Hsp90 with IC50 value <1 μM, also inhibits pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 230 μM (PDK1) and 400 μM (PDK3).

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Biological Activity

Radicicol is an inhibitor of Hsp90 with IC50 value <1 μM, also inhibits pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 230 μM (PDK1) and 400 μM (PDK3).
Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.
Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 16 uM.

Physicochemical Properties

M.Wt 364.78
Formula C18H17ClO6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione

References

1. Kato M, et al. Structure. 2007 Aug;15(8):992-1004. Epub 2007 Aug 2.

2. Chalapareddy S, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4341-52.

3. Wang R, et al. Mol Pharm. 2018 Sep 4;15(9):4092-4098.

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