Chemical Structure : Radicicol
CAS No.: 12772-57-5
Catalog No.: PC-23745Not For Human Use, Lab Use Only.
Radicicol is an inhibitor of Hsp90 with IC50 value <1 μM, also inhibits pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 230 μM (PDK1) and 400 μM (PDK3).
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Radicicol is an inhibitor of Hsp90 with IC50 value <1 μM, also inhibits pyruvate dehydrogenase kinase (PDHK, PDK) with IC50 of 230 μM (PDK1) and 400 μM (PDK3).
Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB.
Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 16 uM.
M.Wt | 364.78 | |
Formula | C18H17ClO6 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione |
1. Kato M, et al. Structure. 2007 Aug;15(8):992-1004. Epub 2007 Aug 2.
2. Chalapareddy S, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4341-52.
3. Wang R, et al. Mol Pharm. 2018 Sep 4;15(9):4092-4098.
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