Chemical Structure : Raltegravir
CAS No.: 518048-05-0
Catalog No.: PC-42548Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
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A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM; essentially inactive (IC50s>50 uM) against HCV Pol, HIV RT, HIV RNase-H, and human α/β/γ Pol; shows inhibitory activity against the wild type virus and a selection of mutants; the first HIV-integrase inhibitor for the treatment of HIV-1 infection.
HIV Infection
Approved
M.Wt | 444.4164 | |
Formula | C20H21FN6O5 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo- |
1. Summa V, et al. J Med Chem. 2008 Sep 25;51(18):5843-55.
2. Malet I, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1351-8.
3. Cooper DA, et al. N Engl J Med. 2008 Jul 24;359(4):355-65.
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