Ramatroban | TxA2 inhibitor | Probechem Biochemicals

Chemical Structure : Ramatroban

CAS No.: 116649-85-5

Ramatroban (BAY u3405)

Catalog No.: PC-21315Not For Human Use, Lab Use Only.

Ramatroban (BAY u3405) is a potent selective thromboxane A2 (TxA2) antagonist with IC50 of 14 nM, also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

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Biological Activity

Ramatroban (BAY u3405) is a potent selective thromboxane A2 (TxA2) antagonist with IC50 of 14 nM, also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

Physicochemical Properties

M.Wt	416.47
Formula	C21H21FN2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(3-(4-Fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid

References

1. Stearns BA, et al. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51.

2. Sugimoto H, et al. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52.

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Ramatroban (BAY u3405)

Biological Activity

Physicochemical Properties

References

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