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Ranolazine dihydrochloride

Chemical Structure : Ranolazine dihydrochloride

CAS No.: 95635-56-6

Ranolazine dihydrochloride (RS-43285, CVT 303)

Catalog No.: PC-45224Not For Human Use, Lab Use Only.

Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ranolazine dihydrochloride is an anti-ischemic agent that has been shown to inhibit late I(Na) and I(Kr) and to have antiarrhythmic effects in various preclinical in vitro models.
Ranolazine dihydrochloride also inhibits cardiac sodium channel Nav1.5, shows antiarrhythmic, antiepileptic, and analgesic effects.

Physicochemical Properties

M.Wt 500.4584
Formula C24H35Cl2N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Piperazineacetamide, N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride (1:2)

References

1. Sokolov S, et al. Front Pharmacol. 2013 Jun 21;4:78.

2. Noble D, et al. Heart. 2006 Jul;92 Suppl 4:iv1-iv5.

3. Wang WQ, et al. J Pharmacol Exp Ther. 2008 Jun;325(3):875-81.

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