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Rapastinel

Chemical Structure : Rapastinel

CAS No.: 117928-94-6

Rapastinel (GLYX-13;Thr-Pro-Pro-Thr-NH2)

Catalog No.: PC-45064Not For Human Use, Lab Use Only.

A tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist; readily crosses the blood-brain barrier and modulates the NMDA receptor, shows potent cognitive-enhancing properties in a valid in vivo model of learning.

Depression

Phase 3 Clinical

Physicochemical Properties

M.Wt 413.4686
Formula C18H31N5O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL

Chemical Name/SMILES

L-Threoninamide, L-threonyl-L-prolyl-L-prolyl-

References

1. Moskal JR, et al. Neuropharmacology. 2005 Dec;49(7):1077-87.

2. Zhang XL, et al. Neuropharmacology. 2008 Dec;55(7):1238-50.

3. Burgdorf J, et al. Neurobiol Aging. 2011 Apr;32(4):698-706.

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