Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) is a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist.
Rapastinel readily crosses the blood-brain barrier and modulates the NMDA receptor.
Rapastinel shows potent cognitive-enhancing properties in a valid in vivo model of learning.
Physicochemical Properties
M.Wt
413.4686
Formula
C18H31N5O6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 32 mg/mL
Chemical Name/SMILES
L-Threoninamide, L-threonyl-L-prolyl-L-prolyl-
References
1. Moskal JR, et al. Neuropharmacology. 2005 Dec;49(7):1077-87.
2. Zhang XL, et al. Neuropharmacology. 2008 Dec;55(7):1238-50.
3. Burgdorf J, et al. Neurobiol Aging. 2011 Apr;32(4):698-706.
