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Rapastinel trifluoroacetate

Chemical Structure : Rapastinel trifluoroacetate

CAS No.: 1435786-04-1

Rapastinel trifluoroacetate (GLYX-13, Thr-Pro-Pro-Thr-NH2 TFA)

Catalog No.: PC-22608Not For Human Use, Lab Use Only.

Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) trifluoroacetateis a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist.

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Biological Activity

Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) trifluoroacetateis a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist.
Rapastinel readily crosses the blood-brain barrier and modulates the NMDA receptor.
Rapastinel shows potent cognitive-enhancing properties in a valid in vivo model of learning.

Physicochemical Properties

M.Wt 527.50
Formula C20H32F3N5O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(L-threonyl-L-prolyl)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate

References

1. Moskal JR, et al. Neuropharmacology. 2005 Dec;49(7):1077-87.

2. Zhang XL, et al. Neuropharmacology. 2008 Dec;55(7):1238-50.

3. Burgdorf J, et al. Neurobiol Aging. 2011 Apr;32(4):698-706.

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